Manhattan Scientifics Announces New CEO

Appoints Three New Members To Its Board Of Directors

November 1, 2007

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New York City-- Manhattan Scientifics Inc. (Pink Sheets: MHTX) is pleased to announce that Emmanuel (Manny) Tsoupanarias has been named as the company Chief Executive Officer effective November 1, 2007. Tsoupanarias brings to Manhattan Scientifics more than 15 years of senior management and executive experience in the power generation manufacturing sector.

Tsoupanarias has spent over a decade designing and running a state-of-the-art manufacturing plant producing highest quality standard materials for the power and the nuclear industries.

Tsoupanarias is also the founder and editor of FuelCellWorks.com, a weekly trade publication that has become the voice of the fuel cell industry. Tsoupanarias is internationally recognized as an expert in fuel cell development.

Tsoupanarias, said, “I am excited to lead Manhattan Scientifics during this exciting new phase in its development. The company has recently purchased an overhanging block of 43 million shares and is preparing to file all of its past due SEC reports so that the stock can be eligible for trading on the Over-the-Counter Bulletin Board. Manhattan is poised to move forward with commercializing its assets and I look forward to implementing a new growth plan.”

Marvin Maslow, in his new role as non-executive-chairman of Manhattan Scientifics said, “Our company has a new-face, new capital, and a highly qualified new CEO who knows how to bring product to the market. We feel that Manny’s background in the fuel cell industry will be a major asset for our company going forward. We are pleased to welcome Manny and three additional board members, Leonard Friedman, Frank Georgiou and Chris Theoharis. We feel that their combined industry knowledge will help Manhattan to reach new levels of growth to bring greater returns to our shareholders.”

Georgiou, said, “We intend to explore the re-invention of this company through technology and corporate acquisition. We are focused on ‘green’ environmentally friendly industries as well as alternative energy.

About Manhattan Scientifics

Manhattan Scientifics, Inc. (www.mhtx.com) is located in New Mexico, New York and Montreal. It is focused on technology transfer and commercialization of disruptive technologies in the nano medicine space. The company is presently developing commercial medical prosthetics applications for its ultra-fine grain metals and plans to commercialize the cancer research work and nano medical applications developed by Senior Scientific LLC, a unit of the Company.

Forward-looking statement

This press release contains forward-looking statements. Such forward-looking statements are subject to a number of risks, assumptions and uncertainties that could cause the Company's actual results to differ materially from those projected in such forward-looking statements. Forward-looking statements speak only as of the date made and are not guarantees of future performance. We undertake no obligation to publicly update or revise any forward-looking statements.